Heart failure & cardiomyopathies

A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry

Eur Heart JPublished Prognostic model development and internal validation study

Authors' conclusion

A model which accurately predicts LV recovery at 6 months in women with PPCM was derived.

Study context

Population
Women with peripartum cardiomyopathy (peripartum state, HF signs or symptoms, LV ejection fraction (LVEF) ≤ 45%), ESC EORP PPCM Registry, 51 countries, 2012–2018465 with 6-month echocardiogram
Participants
752 women
Outcome
LV recovery (LVEF ≥50%)
Follow-up
6 months
Methodological detailsregistry, multinational registry, bootstrap internal validation
  • Registry
  • Multinational registry
  • Bootstrap internal validation

Performance

As reported in the abstract

Prediction of LV recovery at 6 months (ESC EORP PPCM Recovery Score)

Left ventricular (LV) recovery occurred

216

46.5%

Model discrimination, C-statistic

0.79

95% CI 0.74–0.83

Optimism-corrected C-statistic, internal validation

0.78

95% CI 0.73–0.82

Original publication

A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry. Eur Heart J. Published 29 January 2024. doi:10.1093/eurheartj/ehad888

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