Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study
Authors' conclusion
These findings suggest that neutrophils may represent a promising target for preventing atherosclerosis.
Study context
- Population
- Secondary prevention patients on long-term dietary intervention (Mediterranean or low-fat diet)
- Comparison
- Neutrophil count (tertiles) and neutrophil-related ratios vs IMT-CC; Mediterranean vs low-fat diet
- Primary endpoint
- Association of absolute neutrophil count and neutrophil-related ratios with IMT-CC
- Follow-up
- Baseline and after 5 and 7 years
Methodological detailslong-term secondary prevention, longitudinal analysis
- Long-term secondary prevention
- Longitudinal analysis
Primary result
As reported in the abstract
baseline
Elevated neutrophil count and IMT-CC >.9 mm
OR 1.17
95% CI 1.04–1.35
Elevated neutrophil-to-erythrocyte ratio and IMT-CC >.9 mm
OR 2.21
95% CI 1.24–4.12
Elevated neutrophil-to-HDL ratio and IMT-CC >.9 mm
OR 1.96
95% CI 1.09–3.55
Further findings
IMT-CC change per 1 unit neutrophils/μl (linear mixed-effect model) · 5 and 7 years
- Mean increase in IMT-CC, fully adjusted
- .004 (.002) mm, P = .031
Neutrophil count in patients with IMT-CC regression at 7 years, Mediterranean diet · 5 and 7 years vs baseline
- Significant decrease in neutrophil count vs baseline
- both P < .05
Original publication
Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study. Eur Heart J. Published 11 December 2024. doi:10.
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