Heart failure & cardiomyopathies
Updated quantitative thresholds for cardiac magnetic resonance imaging–based diagnosis of arrhythmogenic right ventricular cardiomyopathy
Authors' conclusion
Incorporation of modern standards for normal RV structure and function improved the specificity of the ARVC modified task force criteria without reducing sensitivity.
Study context
- Population
- Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) with available quantitative cardiac magnetic resonance (CMR), Johns Hopkins ARVC Center
- Participants
- 430 patients
- Exposure
- Updated CMR thresholds vs 2010 modified task force criteria for right ventricular (RV) dilation and systolic dysfunction
- Outcome
- Reclassification of RV diagnostic criteria using updated standards for RV structure and function
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Reclassification with updated CMR standards
- Major RV structure/function criteria downgraded to minor criteria
- 18.3%
- Major RV structure/function criteria downgraded to no criteria fulfillment
- 10.5%
- Minor RV structure/function criteria downgraded to no criteria fulfillment
- 35.0%
- Patients downgraded to borderline diagnosis
- 1
- Patients downgraded to no ARVC diagnosis
- 3
Observational data: associations, not effects.
Further findings
Baseline CMR measures
- Mean RV end-diastolic volume index
- 114 mL/m² (±39)
- Mean RV EF
- 41% (±11%)
Ventricular arrhythmia after reversed diagnosis · follow-up
- Patient with reversed ARVC diagnosis developing ventricular arrhythmia, with alternative diagnosis of LMNA-related cardiomyopathy
- 1
Original publication
Updated quantitative thresholds for cardiac magnetic resonance imaging–based diagnosis of arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. Published 27 November 2025. doi:10.
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