Heart failure & cardiomyopathies
Use of Heart Failure Medical Therapy Before and After a Cancer Diagnosis: A Longitudinal Study
Authors' conclusion
Following a cancer diagnosis, patients with HFrEF were more likely to have reduced use of GDMTs for HF.
Study context
- Population
- Patients with probable HF with reduced ejection fraction (HFrEF) in UK primary care records, 2005–20214,890 matched to controls
- Participants
- 8,504 patients
- Exposure
- HFrEF patients with incident cancer vs matched HFrEF patients without cancer
- Outcome
- GDMT (renin-angiotensin-system inhibitors (RASIs), beta-blockers, mineralocorticoid receptor antagonists (MRAs)) adherence, persistence, initiation and dose titration
- Follow-up
- 12 months after cancer diagnosis
Methodological details1:1 matched, UK Clinical Practice Research Datalink, 2005–2021
- 1:1 matched
- UK Clinical Practice Research Datalink, 2005–2021
Main finding
As reported in the abstract
Cancer vs Non-cancer controlsOdds ratio (95% CI)
Poor adherence, RASIs
1.51(1.35–1.68)
Poor adherence, beta-blockers
1.22(1.08–1.37)
Poor adherence, MRAs
1.31(1.08–1.59)
Poor persistence, RASIs
2.04(1.75–2.37)
Poor persistence, beta-blockers
1.35(1.12–1.63)
Poor persistence, MRAs
1.49(1.16–1.93)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Dose down-titrationCancervs Non-cancer controlsRASIs | 1.69 (1.40–2.04) | |
| Dose down-titrationCancervs Non-cancer controlsBeta-blockers | 1.31 (1.05–1.62) | |
| 0.512Odds ratio (log scale) |
Treatment initiation and dose up-titration
- Cancer diagnosis not associated with treatment initiation or dose up-titration
Heart failure (HF) hospitalisation and mortality by adherence/persistence
- Higher event rates with poor adherence or persistence to guideline-directed medical therapies (GDMTs)
Original publication
Use of Heart Failure Medical Therapy Before and After a Cancer Diagnosis: A Longitudinal Study. ESC Heart Fail. Published 23 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →