Arrhythmias & electrophysiology
Validation of Left Ventricular Filling Pressure Evaluation by Order of Tricuspid and Mitral Valve Opening in Patients With Atrial Fibrillation
Authors' conclusion
VMT scoring was a useful echocardiographic marker of elevated left ventricular filling pressure and had an incremental benefit over practical biomarkers in patients with AF.
Study context
- Population
- Patients with AF (or flutter) undergoing cardiac catheterizationexternal validation n = 189
- Participants
- 119 patients
- Comparison
- VMT score vs conventional Doppler parameters for elevated LV filling pressure
- Outcome
- Elevated LV filling pressure (mean pulmonary arterial wedge pressure ≥15 mm Hg)
Methodological detailsderivation cohort, external validation cohort, consecutive patients
- Derivation cohort
- External validation cohort
- Consecutive patients
Performance
As reported in the abstract
Prediction of elevated pulmonary arterial wedge pressure (derivation cohort)
| Test or model | C index | Accuracy (VMT≥2) |
|---|---|---|
| VMT score | 0.88 | 87% |
| Conventional Doppler parameters | 0.54-0.68 | — not stated in the abstract |
C index
VMT score0.88
Conventional Doppler parameters0.54-0.68
Accuracy (VMT≥2)
VMT score87%
Conventional Doppler parameters— not stated in the abstract
— not stated in the abstract
- VMT score vs Conventional Doppler parameters: P < 0.001 — 0.88 vs 0.54-0.68
Further findings
| Outcome | C index | P value |
|---|---|---|
| Diagnostic accuracy of VMT ≥2 vs conventional Doppler parametersDoppler C index 0.54-0.68 | 0.88 | P < 0.001 |
VMT ≥2 incremental value over plasma BNP
- C index
- 0.79-0.93
- P<0.001
Accuracy of VMT≥2 in external validation cohort
- VMT≥2 accuracy
- 72%
- External validation cohort, 189 patients with AF
Original publication
Validation of Left Ventricular Filling Pressure Evaluation by Order of Tricuspid and Mitral Valve Opening in Patients With Atrial Fibrillation. Circ Cardiovasc Imaging. Published 13 November 2024. doi:10.
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