Arrhythmias & electrophysiology
aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study
Main finding · Primary endpoint (SCD, sustained VAs or appropriate ICD interventions)Result — go to the resultOdds ratio 2.2Authors' conclusion
Among patients with IAS and AAs, AA is the first clinical manifestation in about half of the cases, with more than one form of AAs present in one-fourth of the patients. The occurrence of AA earlier in life may be associated with a higher risk of VAs. The occurrence of stroke and sinus node dysfunction is not infrequently in this cohort.
Study context
- Population
- Patients with inherited arrhythmia syndrome (IAS) and ECG-documented atrial arrhythmias (AAs)
- Participants
- 522 patients
- Exposure
- First AA <20 years vs First AA ≥20 years
- Outcome
- Composite of:
- SCD
- Sustained ventricular arrhythmias
- Appropriate ICD interventions
Methodological detailsinternational, 28 centres in 16 countries
- International
- 28 centres in 16 countries
Main finding
As reported in the abstract
- SCD
- Sustained ventricular arrhythmias (VAs)
- Appropriate ICD interventions
Odds ratio
2.2
P = 0.043
- Incidence of primary endpoint
- 1.4% per year
Observational data: associations, not effects.
Further findings
Distribution of IAS
- Brugada syndrome
- n = 355, 68%
- Long QT syndrome
- n = 93, 18%
- Other IAS
- n = 71, 14%
Distribution and presentation of AAs
- AF
- 82%
- Atrial flutter
- 9%
- Atrial tachycardia
- 9%
- AA as first clinical manifestation of IAS
- 52%
- More than one type of AA
- 23%
Safety
VA before IAS diagnosis due to anti-arrhythmic medications for AA
- Patients with VA
- Nine patients (3%)
Inappropriate implantable cardioverter defibrillator (ICD) shock due to AAs, stroke, sinus node dysfunction
- Inappropriate ICD shock due to AAs
- 2.8%
- Stroke
- 4.4%
- Sinus node dysfunction
- 9.6%
Original publication
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