Value of cardiovascular magnetic resonance–derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion
Authors' conclusion
Addition of fully automated MBF quantification to clinical routine visual S-CMR reading facilitates non-invasive differentiation between CTO and severe stenosis and provides higher sensitivity regarding true ischaemic burden in patients with CTO and multi-vessel disease
Study context
- Population
- Consecutive patients undergoing stress perfusion CMR and coronary angiography, February 2023–November 2024
- Participants
- 130 patients
- Comparison
- Fully automated quantitative myocardial blood flow (MBF) assessment by stress perfusion CMR in chronic total occlusion (CTO) vs severe stenosis vs non-obstructed coronary arteries
- Non-obstructedn = 57reference
- Severe stenosisn = 37
- CTOn = 36
- Outcome
- Diagnostic performance of CMR-derived fully automated quantitative MBF assessment in CTO
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Performance
As reported in the abstract
Segmental stress MBF <1.02 mL/g/min to differentiate CTO from severe stenosis
| Test or model | AUC (vs severe stenosis) |
|---|---|
| CTO | 0.792 (95% CI 0.678-0.887) |
CTO
AUC (vs severe stenosis)0.792 (95% CI 0.678-0.887)
Further findings
| Outcome | CTO |
|---|---|
| Detection of additional severe stenosis in CTO patients by integrated visual and quantitative perfusion assessment | |
| Sensitivity | 91.3% |
Original publication
Value of cardiovascular magnetic resonance–derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion. Eur Heart J Cardiovasc Imaging. Published 8 September 2025. doi:10.
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