High-resolution free-breathing automated quantitative myocardial perfusion by cardiovascular magnetic resonance for the detection of functionally significant coronary artery disease
Authors' conclusion
A novel scanner-integrated high-resolution free-breathing SP-CMR sequence with automated in-line perfusion mapping is presented which accurately detects functionally significant CAD.
Study context
- Population
- Patients with suspected coronary artery disease (CAD) undergoing stress perfusion cardiovascular magnetic resonance (SP-CMR) at 3 T and invasive coronary angiography (ICA) within 6 months703 recruited
- Participants
- 80 patients
- Comparison
- High-resolution free-breathing SP-CMR with automated quantitative perfusion mapping vs ICA with fractional flow reserve (FFR)
- Outcome
- Detection of FFR-positive (≤0.80) CAD per vessel
Methodological details3 Tesla, automated in-line quantitative perfusion mapping
- 3 Tesla
- Automated in-line quantitative perfusion mapping
Performance
As reported in the abstract
Per-vessel detection of FFR-positive CAD
| Test or model | AUC |
|---|---|
| Stress myocardial blood flow (MBF) | 0.85 |
| Myocardial perfusion reserve (MPR) | 0.96 |
AUC
Stress myocardial blood flow (MBF)0.85
Myocardial perfusion reserve (MPR)0.96
Further findings
Coronary territory stress MBF, FFR-positive vs FFR-negative regions
P < 0.001
Median
| Outcome | FFR-positive | FFR-negative | P value |
|---|---|---|---|
| Coronary territory MPR, FFR-positive vs FFR-negative regions | 1.67 (range 1.10–1.89) | 2.35 (range 2.06–2.54) | P < 0.001 |
- Coronary territory stress MBF, FFR-positive vs FFR-negative regions: 75 FFR-assessed vessels and 28 chronic total occlusion (CTO) vessels
Original publication
High-resolution free-breathing automated quantitative myocardial perfusion by cardiovascular magnetic resonance for the detection of functionally significant coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 25 March 2024. doi:10.
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