Prevention & lipidsCohort study
Vendor Independent Coronary Calcium Scoring Improves Individual Risk Assessment
- Calibration development and risk-prediction study
- phantom study
- cohort data from MESA
Authors' conclusion
MESA participants who were reclassified to a higher calcium category by means of the vnAS experienced more CHD events, indicating improved risk categorization.
Study context
- Population
- MESA participants; Computed tomography (CT) systems imaged with anthropomorphic calcium phantomsMESA
- Participants
- 3,181 participants
- Exposure
- Vendor-neutral AS (vnAS) vs original Agatston scores (AS) for coronary heart disease (CHD) risk classification
- Reclassifiedn = 85
- Outcome
- CHD event prediction with vnAS
Main finding
CHD events
Hazard ratio
3.39
95% CI 1.82–6.35
P = 0.001
By group
Reclassified vs Low calcium
HR 3.39 (95% CI 1.82–6.35); P = 0.001
As reported in the abstract
- Originally low calcium participants (n = 781) reclassified to higher risk category by vnAS
- 85 (11%)
Observational data: associations, not effects.
Further findings
Correlation of CT systems with electron beam tomography AS
- Strong correlation for all CT systems (R2)
- >0.932
Original publication
Vendor Independent Coronary Calcium Scoring Improves Individual Risk Assessment. JACC Cardiovasc Imaging. Published 14 June 2023. doi:10.1016/j.jcmg.2023.05.005
Summarised from the published abstract; every number is checked against it