Valvular & structural heart disease
Ventricular Arrhythmias After Self-Expanding Transcatheter Pulmonary Valve Replacement: A Report From the SERVE Registry
Authors' conclusion
This large multicenter registry study of the natural history of VA after SETPV implantation showed VA to be frequent during the procedural admission, with Alterra patients having more VA than Harmony patients. VA burden decreased to lower than baseline at 6 months in Harmony patients and to baseline in Alterra patients.
Study context
- Population
- Patients with a native or surgically repaired right ventricular outflow tract undergoing self-expanding transcatheter pulmonary valve implantation at 25 U.S. centers
- Participants
- 513 SETPV implants
- Exposure
- Alterra vs Harmony
- Alterran = 154
- Harmonyn = 359
- Outcome
- VA during the procedural admission
- Follow-up
- Procedural admission
Main finding
As reported in the abstract
P = 0.014
Observational data: associations, not effects.
Further findings
| Outcome | Harmony | Alterra |
|---|---|---|
| Predicted probability of VA burden vs baseline · 6 months | change from baseline −6% (95% CI −10%–-2%) | |
| P | P < 0.001 | P = 0.53 |
- Predicted probability of VA burden vs baseline: decreased below baseline for Harmony; to baseline for Alterra
Baseline characteristics
- Median age
- 28 years (Q1-Q3: 17-44 years)
- No difference in baseline VA by valve type
Original publication
Ventricular Arrhythmias After Self-Expanding Transcatheter Pulmonary Valve Replacement: A Report From the SERVE Registry. JACC Clin Electrophysiol. Published March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →