Heart failure & cardiomyopathies
Preimplantation AI-ECG Age as a Predictor of Survival Following Cardiac Resynchronization Therapy
Authors' conclusion
Preimplantation AI-ECG-derived δage is an independent predictor of survival post-CRT-D. The lower the AI-ECG age compared to the chronological age, the longer the post-CRT-D survival, possibly reflective of a lower "biologic" age.
Study context
- Population
- Patients with LVEF ≤35%, QRS duration ≥120 ms and cardiac resynchronization therapy with defibrillator (CRT-D) at the Mayo Clinic, 2001–2022
- Participants
- 464 patients
- Exposure
- Preimplantation AI-ECG δage and survival after CRT-D
- Outcome
- All-cause mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Survival post implantation
Time ratio
0.96
P = 0.007
Lower δage (continuous) · multivariable; lower δage correlated with longer survival
Time ratio
0.62
P = 0.017
δage >5.1 years vs δage −5.1 to 5.1 years · shorter survival with δage >5.1 years
Observational data: associations, not effects.
Further findings
Other markers of prolonged survival
- Lower chronological age, nonischemic cardiomyopathy, absence of advanced CKD, and hypertension
Baseline characteristics, δage < 0
- Chronologically older, with greater incidence of hypertension, CAD, hyperlipidemia and peripheral vascular disease
- P < 0.05
Original publication
Preimplantation AI-ECG Age as a Predictor of Survival Following Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. Published 24 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →