Visceral adipose tissue is associated with recurrent cardiovascular events in premature coronary artery disease: sub-analysis of the GEA study cohort
Main finding · Recurrent MACEResult — go to the resultAdjusted hazard ratio 2.71 95% CI 1.37–5.35Authors' conclusion
Among patients with pCAD, VAT increased the risk of recurrent MACE despite adequate pharmacological treatment.
Study context
- Population
- Patients with premature coronary artery disease (CAD) (premature CAD (pCAD)); median age 53 years, 80% male
- Participants
- 853 patients
- Exposure
- Upper vs lower visceral adipose tissue (VAT) tertiles
- Outcome
- Recurrence of MACE
- Follow-up
- 5 years
Methodological detailsVAT measured by CT at baseline, Cox models adjusted for baseline confounders
- VAT measured by CT at baseline
- Cox models adjusted for baseline confounders
Main finding
Recurrent MACE · median follow-up 4.9 years
Adjusted hazard ratio
2.71
95% CI 1.37–5.35
P = 0.004
Uppervs lower VAT tertiles
aHR 2.71 (95% CI 1.37–5.35); P = 0.004
As reported in the abstract
- Overall recurrent major adverse cardiovascular events (MACE)
- 10%
- Incidence rate, events per 1,000 person-years
- 18.5 (95% CI 18.0-19.0)
Observational data: associations, not effects.
Secondary outcomes
Non-fatal MACE
| aHR (95% CI) | P value | ||
|---|---|---|---|
| Upper tertileVAT ≥ 194 cm² | 3.58 (1.49–8.61) | P = 0.004 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Fatal MACE
- Fatal MACE not statistically associated with VAT
- aHR: 2.13; 95% CI: 0.72-6.35; p=0.174
Original publication
Visceral adipose tissue is associated with recurrent cardiovascular events in premature coronary artery disease: sub-analysis of the GEA study cohort. Eur J Prev Cardiol. Published 17 February 2025. doi:10.
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