Stress T1 mapping and quantitative perfusion cardiovascular magnetic resonance in patients with suspected obstructive coronary artery disease
Authors' conclusion
ΔT1 is significantly influenced by sex and comorbidities and has poor diagnostic accuracy for detecting myocardial ischaemia. Therefore, the clinical utility of ΔT1 in a real-world cohort of patients to detect obstructive CAD is limited.
Study context
- Population
- Patients with suspected obstructive coronary artery disease (CAD) who underwent cardiovascular magnetic resonance (CMR) including rest and adenosine stress first-pass perfusion and native T1 mapping (MOLLI)
- Participants
- 51 patients
- Exposure
- CMR-derived ΔT1 vs quantitative perfusion (QP CMR) measures, and ΔT1 to detect obstructive CAD diagnosed with invasive coronary angiography (ICA) and/or fractional flow reserve
- Outcome
- Correlation between pooled rest and stress native T1 mapping and myocardial blood flow
Main finding
As reported in the abstract
- Pearson's r
- 0.476
- P
- P < 0.001
Observational data: associations, not effects.
Further findings
Stress T1 mapping values and ΔT1, ischaemic vs nonischaemic myocardium (stratified by myocardial perfusion reserve (MPR))
- Stress T1 mapping values significantly lower in ischaemic myocardium
- P < 0.001
- ΔT1 significantly lower in ischaemic myocardium
- P = 0.005
Factors associated with ΔT1
- Male sex and history of diabetes independently associated with lower ΔT1
ΔT1 to detect impaired MPR, per-vessel
- Optimal cut-off
- ≤5.4%
- Area under the curve
- 0.662 (95% CI: 0.563-0.752, P = 0.003)
- Sensitivity
- 84% (95% CI: 67-95)
- Specificity
- 46% (95% CI: 34-58)
Stress T1 and ΔT1 validated against ICA for obstructive CAD
- Did not reach statistical significance in detecting obstructive CAD
Original publication
Stress T1 mapping and quantitative perfusion cardiovascular magnetic resonance in patients with suspected obstructive coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 17 February 2025. doi:10.
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