Heart failure & cardiomyopathies
Volume-Weighted Unipolar Voltage Predicts Heart Failure Mortality in Patients With Dilated Cardiomyopathy and Ventricular Arrhythmias
Performance · Prediction of HFOs by vwUVResult — go to the resultHazard ratio 3.68 CI 2.09–6.45Authors' conclusion
The novel parameter vwUV, as a surrogate for the amount of viable myocardium, identifies patients with DCM with VA who are at high risk for HF progression and mortality.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM) referred for catheter ablation of ventricular arrhythmias
- Participants
- 103 patients
- Comparison
- Patients with HFOs vs without HFOs
- HFOsn = 16
- Outcome
- HF-related adverse outcomes (death, heart transplantation or ventricular assist device implantation) predicted by vwUV
Methodological detailsconsecutive patients
- Consecutive patients
Performance
Prediction of HFOs by vwUV
Hazard ratio
3.68
CI 2.09–6.45
P < 0.001
By group
HFOs
5.94
IQR 5.28–6.55
No HFOs
10.37
IQR 8.82–12.81
Patients with HFOsvs without HFOs
HR 3.68 (CI 2.09–6.45); P < 0.001
As reported in the abstract
Further findings
| Outcome | HFOs | No HFOs | P value |
|---|---|---|---|
| LVEF | 29% (SD 10%) | 41% (SD 12%) | P < 0.001 |
| Vw bipolar voltage | 3.00 (IQR 2.47–3.53) | 5.00 (IQR 4.12–5.73) | P < 0.001 |
vwUV, whole cohort
- Median vwUV
- 9.75 (IQR: 7.27-12.29)
Mortality and HFOs during follow-up · median follow-up 24 months (IQR: 8-47 months)
- Died
- 25 (24%)
- HFOs
- 16
- Time to HFOs after ablation
- 7 months (IQR: 1-18 months)
Original publication
Volume-Weighted Unipolar Voltage Predicts Heart Failure Mortality in Patients With Dilated Cardiomyopathy and Ventricular Arrhythmias. JACC Clin Electrophysiol. Published 18 January 2023. doi:10.
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