Heart failure & cardiomyopathies
Why do People with Heart Failure Die? Rationale and Design of the RHYTHM-HF Study
Study context
- Population
- Patients hospitalised with a primary diagnosis of decompensated HF, all receiving an insertable cardiac monitor before discharge
- Participants
- 257 patients
- Primary endpoint
- Cause, mode and mechanism of death (ICM-derived terminal cardiac rhythm and autopsy findings)
- Follow-up
- Up to 4 years
Methodological detailsrationale and design, unselected, near-consecutive, optional autopsy sub-study, remote ICM follow-up, stepwise clinical adjudication, No physical follow-up after discharge; ICM data obtained by remote upload, Adjudication in 3 steps: clinical data alone, plus post-mortem data, plus terminal rhythm data
- Rationale and design
- Unselected
- Near-consecutive
- Optional autopsy sub-study
- Remote ICM follow-up
- Stepwise clinical adjudication
- No physical follow-up after discharge; ICM data obtained by remote upload
- Adjudication in 3 steps: clinical data alone, plus post-mortem data, plus terminal rhythm data
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Why do People with Heart Failure Die? Rationale and Design of the RHYTHM-HF Study. Eur J Heart Fail. Published 29 August 2025. doi:10.
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