Acute cardiac care & resuscitation

Young adults in the cardiac intensive care unit: insights from the Critical Care Cardiology Trials Network registry

Eur Heart J Acute Cardiovasc CarePublished multicentre registry

Authors' conclusion

Young adults admitted to the CICU represent a clinically distinct population, with higher rates of high-acuity presentations and intensive resource use yet lower short-term mortality.

Study context

Population
Adults admitted to advanced cardiac intensive care units (cardiac intensive care unit (CICUs)) in the Critical Care Cardiology Trials NetworkCICU admissions, 6.7% (n = 1959) aged 18–39 years
Participants
29,035 CICU admissions
Exposure
Patients aged 18-39 years compared with those aged ≥40 years
  • Young adultsn = 1,959
Outcome
Female sex
Methodological detailsconsecutive adult CICU admissions, 2018 to 2023, North America
  • Consecutive adult CICU admissions
  • 2018 to 2023
  • North America

Main finding

As reported in the abstract

P = 0.001

Observational data: associations, not effects.

Further findings

Non-White

P < 0.001

Heart failure as admission diagnosis · leading admission diagnosis among young adults

P < 0.001

Cardiogenic shock

P < 0.001

Cardiac arrest

P = 0.003

Mechanical circulatory support

P = 0.02

Extracorporeal membrane oxygenation share of mechanical circulatory support

P < 0.001

CICU mortality · lower in the young

P < 0.001

Hospital mortality · lower in the young

P < 0.001

CICU length of stay

P < 0.001

Non-White

Young adults had fewer traditional cardiovascular risk factors

Original publication

Young adults in the cardiac intensive care unit: insights from the Critical Care Cardiology Trials Network registry. Eur Heart J Acute Cardiovasc Care. Published 19 December 2025. doi:10.1093/ehjacc/zuaf161

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