Arrhythmias & electrophysiology
A mobile relational agent to enhance atrial fibrillation self-care: Primary and secondary outcomes of a randomized controlled trial
Primary result · Adjusted mean PDCResult — go to the resultOdds ratio 1.26 95% CI 0.66–2.38Authors' conclusion
The smartphone-based relational agent intervention did not achieve its primary endpoint of increased anticoagulation adherence but did yield decreased health care utilization.
Study context
- Population
- Individuals with atrial fibrillation (AF) taking anticoagulation
- Participants
- 243 individuals
- Comparison
- Smartphone-based relational agent plus heart rhythm monitor vs smartphone health education app plus the same monitor
- Primary endpoint
- Anticoagulation adherence: proportion of days covered (PDC) from pharmacy claims
- Follow-up
- 12 months
Methodological detailsattention-controlled
- Attention-controlled
Primary result
Adjusted mean PDC
Odds ratio
1.26
95% CI 0.66–2.38
By group
Intervention
0.88
adjusted mean · 95% CI 0.84–0.93
Attention control
0.85
adjusted mean · 95% CI 0.81–0.90
Intervention vs Attention control
OR 1.26 (95% CI 0.66–2.38)
As reported in the abstract
Secondary outcomes
Self-reported nonadherence and quality of life (QOL)
- Did not differ by study arm
Health care utilization
- ED visits and hospitalizations significantly less with intervention than attention control
- P < 0.001
- Number of days hospitalized significantly less with intervention than attention control
- P = 0.004
Original publication
A mobile relational agent to enhance atrial fibrillation self-care: Primary and secondary outcomes of a randomized controlled trial. Am Heart J. Published 20 June 2025. doi:10.
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