Heart failure & cardiomyopathies
A novel polygenic risk score improves prognostic prediction of heart failure with preserved ejection fraction in the Chinese Han population
Authors' conclusion
The HF-PRS comprising 69 genetic variants provided an improvement of prognostic power over the contemporary risk scores and NT-proBNP in HFpEF patients.
Study context
- Population
- HFpEF patients, Chinese Han population
- Participants
- 1,442 patients
- Comparison
- HF-PRS vs clinical risk score
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsmicroarray candidate gene selection, internal cross-validation
- Microarray candidate gene selection
- Internal cross-validation
Performance
As reported in the abstract
Discrimination for 1-year all-cause mortality
Net reclassification improvement (NRI)
0.741
95% CI 0.605–0.877P < 0.001
HF-PRS
Integrated discrimination improvement (IDI)
0.181
95% CI 0.145–0.218P < 0.001
HF-PRS
HF-PRS
0.852
95% CI 0.827–0.877
AUC
Clinical risk score
0.696
95% CI 0.658–0.734
AUC
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by HF-PRS tertileMedium tertilevs Lowest tertile | 5.3 (2.4–11.9) | P = 5.6 × 10-5 | |
| Mortality by HF-PRS tertileHighest tertilevs Lowest tertile | 29.8 (14.0–63.5) | P = 1.4 × 10-18 | |
| 0.050.21520Hazard ratio (log scale) |
Discrimination in cross-validation and subgroups
- Excellent in cross validation and throughout subgroups regardless of comorbidities, gender, and history of heart failure (HF)
Original publication
A novel polygenic risk score improves prognostic prediction of heart failure with preserved ejection fraction in the Chinese Han population. Eur J Prev Cardiol. Published 21 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →