Heart failure & cardiomyopathies
Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury
Authors' conclusion
Tubular injury does not occur in most patients with acute heart failure experiencing WRF, consistent with the functional mechanisms of WRF in this patient population.
Study context
- Population
- Patients hospitalised with acute HF who met KDIGO stage 1 or 2 AKI criteria during the first 3 days of hospitalisationof 927 AKINESIS participants
- Participants
- 175 patients
- Comparison
- Blood and urine biomarkers of cardiac and kidney dysfunction vs adverse outcomes
- Primary endpoint
- Composite of:
- Worsening worsening renal function (WRF) (higher AKI stage)
- Need for dialysis
- Death
- Follow-up
- 30 days
Methodological details24 blood and urine biomarkers measured from specimens collected within 24 hours of meeting AKI criteria
- 24 blood and urine biomarkers measured from specimens collected within 24 hours of meeting AKI criteria
Primary result
As reported in the abstract
Primary composite outcome
Developed the primary composite outcome
32
18%
Highest vs lowest tertile of plasma Gal-3, adjusted for serum creatinine, SBP and blood urea nitrogen: OR
4.6 (1.4-16.0) (95% CI)
Gal-3 AUC
0.70 (0.58-0.82) (95% CI)
Urine epidermal growth factor AUC
0.63 (0.53-0.74) (95% CI)
Further findings
Baseline characteristics by composite outcome
- Only history of CKD significantly different between those with and without the composite outcome
Original publication
Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury. Circ Heart Fail. Published 18 October 2024. doi:10.
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