Heart failure & cardiomyopathies
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury
An erratum to this article was published (Circulation, 19 Jun 2018 ↗)
Authors' conclusion
Kidney tubular injury does not appear to have an association with WRF in the context of aggressive diuresis of patients with acute heart failure.
Study context
- Population
- Patients with acute HF undergoing aggressive diuresis (high-dose loop diuretic) with baseline and 72-hour urine tubular injury biomarkers
- Participants
- 283 patients
- Primary endpoint
- Association of tubular injury biomarkers (NAG, NGAL, KIM-1) with WRF (≥20% decrease in cystatin C-estimated GFR) and with prognosis
- Follow-up
- 72 hours
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
- Worsening renal function (WRF) incidence
- 21.2%
- WRF not associated with increase in NGAL
- P=0.21
- WRF not associated with increase in NAG
- P=0.46
- WRF not associated with increase in KIM-1
- P=0.22
Further findings
Change in tubular injury biomarkers with aggressive diuresis · 72 hours
- NAG and KIM-1 did not change with aggressive diuresis
- both P>0.59
- NGAL decreased slightly (median change; IQR −169 to 35 ng/mg)
- −8.7 ng/mg; P<0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. Circulation. Published 19 January 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →