Acute cardiac care & resuscitation
Kidney Injury in Patients with Heart Failure-Related Cardiogenic Shock: Results from an International, Multicentre Cohort Study
Main finding · 30-day mortality by AKI stageResult — go to the resultAdjusted hazard ratio 1.97 95% CI 1.56–2.48Authors' conclusion
In HF-CS, kidney injury is associated with higher 30-day mortality, potentially mediated by bleeding and sepsis.
Study context
- Population
- Patients with heart failure-related cardiogenic shock (HF-CS), 2010–2021
- Participants
- 1,010 patients
- Exposure
- Acute kidney injury (AKI) stages and severe renal dysfunction vs none
- Outcome
- 30-day mortality by renal function
- Follow-up
- 30 days
Methodological detailsmulticentre, international, 16 tertiary care centres in five countries
- Multicentre
- International
- 16 tertiary care centres in five countries
Main finding
30-day mortality by AKI stage
Adjusted hazard ratio
1.97
95% CI 1.56–2.48
P < 0.001
By group
AKI stage 3vs No AKI
adjusted HR 1.97 (95% CI 1.56–2.48); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Severe renal dysfunction | No severe renal dysfunction | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| 30-day mortality by severe renal dysfunction (eGFR ≤ median) · 21% higher 30-day mortality risk | 61.0% | 40.1% | 1.48 (1.20–1.84) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Baseline renal function · median baseline
- Median baseline creatinine
- 1.7 (IQR 1.2-2.5) mg/dl
- Corresponding estimated glomerular filtration rate (eGFR)
- 41.0 (IQR 25.2-62.2) ml/min/1.73 m²
Sepsis and bleeding
- Sepsis and bleeding associated with both AKI and renal dysfunction, even after adjustment
Original publication
Kidney Injury in Patients with Heart Failure-Related Cardiogenic Shock: Results from an International, Multicentre Cohort Study. Eur J Heart Fail. Published 28 May 2025. doi:10.
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