Arrhythmias & electrophysiology
Acute effects of cardioneuroablation on ventricular arrhythmia inducibility and refractoriness in patients with functional bradyarrhythmias. The Roman 4 study.
Authors' conclusion
The present study did not demonstrate evidence of acute electrophysiological changes suggesting increased ventricular arrhythmogenicity after CNA in patients without structural heart disease. However, long-term follow-up is needed to confirm lack of proarrhythmic effects of CNA.
Study context
- Population
- Patients with functional bradyarrhythmias undergoing cardioneuroablationpatients who underwent cardioneuroablation (CNA) (51 females, mean age 42 ± 14 years)
- Participants
- 80 patients
- Comparison
- Measurements at baseline, immediately after CNA, after atropine injection, and after isoproterenol bolus
- Outcome
- Induced polymorphic ventricular tachyarrhythmias
Main finding
As reported in the abstract
- Induced in females who had pre-existing cardiac conditions
- 2
Further findings
QTc
- Bazett formula: significantly prolonged
- Framingham, Fridericia and Hodges corrections: changes much less pronounced or non-significant
- Changes in QTc depended on the method used for correction
QTd
- Unchanged across all measurements
Ventricular effective refractory period (VERP) and ventricular action potential duration (VAPD)
- Unchanged after CNA and after atropine
- Significantly shorter following isoproterenol injection
Original publication
Acute effects of cardioneuroablation on ventricular arrhythmia inducibility and refractoriness in patients with functional bradyarrhythmias. The Roman 4 study. Heart Rhythm. Published 27 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →