Adulthood adiposity affects cardiac structure and function in later life
Authors' conclusion
Higher adiposity (BMI/WHR) over adulthood is associated with evidence of adverse cardiac structure and function. Some of these associations are independent of adiposity in later life.
Study context
- Population
- National Survey of Health and Development birth cohort participants with repeated adiposity measurements over adulthood and echocardiography at age 60–64 years
- Participants
- 1,690 participants
- Exposure
- Adulthood adiposity vs cardiac structure and function at age 60-64 years
- Outcome
- Left ventricular (LV) structure (LVM, relative wall thickness, LVIDd) and function (diastolic: E/e', e', LA volume indexed to body surface area; systolic: EF, S', myocardial contraction fraction)
- Follow-up
- Age 60-64 years
Main finding
As reported in the abstract
- Increased body mass index (BMI) from age 20 y onwards associated with greater LV mass (LVM) and LV internal diameter in diastole (LVIDd), independent of confounders; independent of current BMI for LVIDd, and at age 26, 43 and 53 y for LVM
- Increased BMI from 43 y onwards associated with greater relative wall thickness, but not when BMI at 60-64 y accounted for
- Increased BMI at age 26, 36 and 53 y and at 20 y onwards associated with lower EF and myocardial contraction fraction, respectively, but not independently of BMI at 60-64 y
- Higher BMI from 20 y onwards associated with poorer diastolic function, independent of confounders; associations with LA volume indexed to body surface area persisted from 26 y onwards after adjustment for BMI at 60-64 y
- Similar relationships for waist-to-hip ratio (WHR) from age 43 y onwards
- Multivariable linear regression
Observational data: associations, not effects.
Original publication
Adulthood adiposity affects cardiac structure and function in later life. Eur Heart J. Published 16 July 2024. doi:10.
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