Prevention & lipidsCohort study
Air pollution, meteorological factors, and cardiac remodelling in children: a multi-omics cohort study
- Prospective cohort study
- multi-omics
- multicentre (3 provinces)
Authors' conclusion
This study provided new evidence of air pollution and meteorological factors in children's cardiovascular health
Study context
- Population
- Children in the Southwest Health Children Cohort, Chongqing, Guizhou and Sichuan provinces, China, 2021–2025enrolled at baseline
- Participants
- 2,029 children
- Exposure
- Exposure to PM2.5, temperature, extreme temperature events and relative humidity
- Outcome
- Cardiovascular structure and function by echocardiography
Main finding
As reported in the abstract
Cardiovascular structure and function remodelling · pregnancy to full exposure windows
- PM2.5, temperature (TE), extreme temperature events (ETEs) and relative humidity (RH) exposure significantly associated with cardiovascular remodelling, including carotid intima thickening and decreased EF
Observational data: associations, not effects.
Further findings
Cardiovascular remodelling, by family income and BP (subgroups)
- Associations more pronounced in children from low-income families or with elevated BP
PM2.5 × ETEs interaction
- PM2.5 synergistically interacted with ETEs to promote abnormal cardiovascular remodelling
Biomarkers
- Hexosylceramide, phosphoenolpyruvate, triacylglyceride and myosin light chain 3 identified as important biomarkers linking environmental hazards with abnormal remodelling
Original publication
Air pollution, meteorological factors, and cardiac remodelling in children: a multi-omics cohort study. Eur Heart J. Published 9 January 2026. doi:10.1093/eurheartj/ehaf1086
Summarised from the published abstract; every number is checked against it