The proteomic profile of leisure time physical activity across two decades: implications for future cardiovascular risk and mortality
Authors' conclusion
These findings confirm and extend our understanding of how physical activity could assert its beneficial effect on cardiovascular health through proteins involved with modulating inflammatory, immune, and metabolic pathways.
Study context
- Population
- Men of the Uppsala Longitudinal Study of Adult Men (physical activity self-reported at ages 50, 60 and 70; proteins at age 70); MIMI nested case-cohort from six European cohortscase-cohort: 420 cases, 1598 controls
- Participants
- 782 men
- Exposure
- Higher vs lower cumulative leisure time physical activity
- Outcome
- Associations of leisure time physical activity cumulated over 20 years with 720 plasma proteins
Methodological detailsmulticohort (six European cohorts)
- Multicohort (six European cohorts)
Main finding
As reported in the abstract
Plasma proteins inversely associated with higher physical activity
- Plasma proteins inversely associated with higher leisure time physical activity (adjusted)
- 12
Observational data: associations, not effects.
Further findings
Imminent myocardial infarction (MI), interleukin-6 (MIMI case-cohort) · within 6 months of blood draw
| HR (95% CI) | ||
|---|---|---|
| Interleukin-6Increased incidence of imminent MI | 1.22 (1.09–1.37) | |
| 0.512Hazard ratio (log scale) |
Long-term MI, tumour necrosis factor receptor superfamily member 11A · up to 19.3 years
| HR (CI) | ||
|---|---|---|
| Tumour necrosis factor receptor superfamily member 11AIncreased long-term MI incidence | 1.22 (1.01–1.48) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (CI) |
|---|---|
| Mortality, 11 of the 12 proteins · up to 26.3 yearsIncreased mortality | 1.14-1.30 (1.01–1.42) |
Original publication
The proteomic profile of leisure time physical activity across two decades: implications for future cardiovascular risk and mortality. Eur J Prev Cardiol. Published 8 January 2026. doi:10.
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