Anatomical/Physiological Correlates of Functional Capacity in Adults With Repaired and Nonsevere Coarctation of the Aorta
Authors' conclusion
In patients with nonsevere native or recurrent CoA, reduced exercise capacity is correlated with coarctation severity by anatomic size and gradients.
Study context
- Population
- Adults with nonsevere native or recurrent coarctation of the aorta (CoA) (repaired or unrepaired), single institution, 2015–2020
- Participants
- 54 adults
- Exposure
- Coarctation-to-diaphragm ratio ≤0.7 vs >0.7
- Outcome
- Anatomic and physiologic correlates of exercise capacity (exercise stress echocardiography, MRI)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Correlates of exercise capacity
- Coarctation-to-diaphragm ratio vs minutes of exercise
- r = 0.56, P < 0.01
- Coarctation-to-diaphragm ratio vs metabolic equivalents
- r = 0.49, P < 0.01
- Minutes of exercise vs mean resting gradient
- r = −0.39, P < 0.05
- Coarctation-to-diaphragm ratio vs peak resting gradient
- r = −0.34, P < 0.05
- Coarctation-to-diaphragm ratio vs mean resting gradient
- r = −0.48, P < 0.01
Observational data: associations, not effects.
Further findings
Minutes of exercise
P < 0.05
| Outcome | Ratio ≤0.7 | Ratio >0.7 | P value |
|---|---|---|---|
| Metabolic equivalents achieved | 11.1 ± 1.9 | 12.8 ± 2.2 | P < 0.05 |
Original publication
Anatomical/Physiological Correlates of Functional Capacity in Adults With Repaired and Nonsevere Coarctation of the Aorta. JACC Adv. Published 27 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it