Arrhythmias & electrophysiology
Anterior mitral line in patients with persistent atrial fibrillation and anterior scar: A multicenter matched comparison—The MiLine study
Main findingResult — go to the resultHazard ratio 0.46Authors' conclusion
In this retrospective matched analysis of patients with persistent AF and anterior scar, AML in addition to standard treatment was associated with improved AF/AT-free survival compared to standard treatment alone.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) and anterior atrial scar (anterior low-voltage zone) undergoing ablation2 matched groups (1:1)
- Participants
- 114 patients
- Exposure
- Anterior mitral line (AML) plus standard ablation vs standard ablation alone
- Outcome
- AF/AF/atrial tachycardia (AT) recurrence
- Follow-up
- Median 2 years
Methodological detailsmatched 1:1, multicentre (3 centres), Matched on age, low-voltage zone (LVZ) burden and repeated ablation
- Matched 1:1
- Multicentre (3 centres)
- Matched on age, LVZ burden and repeated ablation
Main finding
As reported in the abstract
Hazard ratio
0.46
P = 0.003
By group
Observational data: associations, not effects.
Further findings
| Outcome | AML | HR | P value |
|---|---|---|---|
| Left atrial volume and AF/AT recurrence (Cox multivariate) | 1.03 | P = 0.006 | |
| Bidirectional conduction block | 95% |
Predictors of first-pass AML block (univariate logistic regression)
- Lower BMI, older age, extensive anterior LVZ and LA activation breakthrough away from the AML associated with first-pass AML block
Original publication
Anterior mitral line in patients with persistent atrial fibrillation and anterior scar: A multicenter matched comparison—The MiLine study. Heart Rhythm. Published 11 January 2023. doi:10.
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