Quantifying Triglyceride-Rich Lipoprotein Atherogenicity, Associations With Inflammation, and Implications for Risk Assessment Using Non-HDL Cholesterol
Authors' conclusion
TRL/remnants are about 4 times more atherogenic than LDL.
Study context
- Population
- UK Biobank; Single nucleotide polymorphisms (SNPs) ranked into 10 clusters by effect on TRL/remnant-C vs LDL-C1,357 SNPs
- Comparison
- TRL/remnant-predominant vs low-density lipoprotein (LDL)-predominant SNP clusters
- Outcome
- CHD (MI plus revascularization) OR per 10 mg/dL apoB and per 0.33 mmol/L non-HDL-C
Methodological detailsgenome-wide association, UK Biobank
- Genome-wide association
- UK Biobank
Main finding
As reported in the abstract
CHD OR per 10 mg/dL higher apoB
Cluster 1
1.15
OR · 95% CI 1.11–1.19
Cluster 10
1.70
OR · 95% CI 1.52–1.90
- TRL/remnants at least times more atherogenic than LDL per particle
- 3.9 (95% CI: 2.8-5.4)
Further findings
Coronary heart disease (CHD) OR per 0.33 mmol/L non-HDL-C
| Population | OR (95% CI) | |
|---|---|---|
| Cluster 10 | 1.40 (1.30-1.50) | |
| 0.512Odds ratio (log scale) |
Inflammation
- TRL/remnants causally related to inflammation, which did not explain their greater atherogenicity
Original publication
Quantifying Triglyceride-Rich Lipoprotein Atherogenicity, Associations With Inflammation, and Implications for Risk Assessment Using Non-HDL Cholesterol. J Am Coll Cardiol. Published 1 October 2024. doi:10.
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