Clinical Course of TGA After Arterial Switch Operation in the Current Era
Authors' conclusion
TGA-ASO patients have an excellent survival. However, their clinical course is characterized by an ongoing need for (re-)interventions, especially on the right ventricular outflow tract and the left ventricular outflow tract
Study context
- Population
- Patients with arterial switch operation for transposition of the great arteries (TGA-ASO); median age 10.7 yearsmedian follow-up 8.0 years
- Participants
- 1,061 patients
- Outcome
- Late survival, (re-)interventions and clinical events (cumulative incidence, age as time scale)
- Follow-up
- Age 35 years
Methodological detailsnationwide registry
- Nationwide registry
Main finding
As reported in the abstract
- Late survival
- 93% (95% CI: 88%-98%)
- Re-intervention, RV outflow tract and pulmonary branches
- 36% (95% CI: 31%-41%)
- Re-intervention, LV outflow tract (neo-aortic root and valve)
- 16% (95% CI: 10%-22%)
- Re-intervention, aortic arch
- 9% (95% CI: 5%-13%)
- Re-intervention, coronary arteries
- 3% (95% CI: 1%-6%)
- Electrophysiological interventions
- 11% (95% CI: 6%-16%)
- Clinical events (HF, endocarditis, MI)
- 8% (95% CI: 5%-11%)
Observational data: associations, not effects.
Further findings
Independent risk factors for any (re-)intervention
| Comparison | HR (95% CI) | |
|---|---|---|
| Taussig-Bing double outlet RVTGA morphological subtype | 4.9 (2.9–8.1) | |
| Previous pulmonary artery banding | 1.6 (1.0–2.2) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Clinical Course of TGA After Arterial Switch Operation in the Current Era. JACC Adv. Published 27 December 2023. doi:10.
Summarised from the published abstract; every number is checked against it