Prevention & lipids

Associations of Dietary Calcium and Phosphorus With Vascular and Valvular Calcification: The ARIC Study

JACC AdvPublished Prospective cohort study

Main finding · Coronary artery calcification (Agatston score ≥75th percentile), calcium intakeResult — go to the resultAdjusted odds ratio 0.66 95% CI 0.45–0.98

Authors' conclusion

Dietary calcium and phosphorus intakes at middle age were not positively associated with vascular and valvular calcification at over 75 years old.

Study context

Population
ARIC participants without CHD (mean age 80.5 years) with chest CT at visit 7 (2018–2019) and FFQ at visits 1 and 3
Participants
1,914 participants
Exposure
Highest vs lowest quartile of dietary calcium and phosphorus intake in middle age
Outcome
Coronary artery and extra-coronary calcification (Agatston score in coronary artery, ascending and descending aorta, aortic valve ring, aortic valve, mitral valve)
Follow-up
Visit 7 (2018-2019)

Main finding

As reported in the abstract

Coronary artery calcification (Agatston score ≥75th percentile), calcium intake

Adjusted odds ratio

0.66

95% CI 0.45–0.98

Highest quartilevs Lowest quartile
adjusted OR 0.66 (95% CI 0.45–0.98)

Observational data: associations, not effects.

Original publication

Associations of Dietary Calcium and Phosphorus With Vascular and Valvular Calcification: The ARIC Study. JACC Adv. Published 20 May 2024. doi:10.1016/j.jacadv.2024.100993

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