Arterial Switch for Transposition of the Great Arteries: Treatment Timing, Late Outcomes, and Risk Factors
Authors' conclusion
Mortality and hospital resource utilization are low, while reintervention remains relatively frequent.
Study context
- Population
- Patients undergoing arterial switch operation (ASO) for transposition of the great arteries with intact ventricular septum, England and Wales, 2000–2017
- Participants
- 1,772 patients
- Outcome
- Survival, reintervention and hospital resource utilization after ASO
Methodological detailsnational dataset, multivariable regression, matching
- National dataset
- Multivariable regression
- Matching
Main finding
As reported in the abstract
- Mortality at 10 years after ASO
- 3.2% (95% CI: 2.5%-4.2%)
- Cardiac reintervention at 10 years after ASO
- 10.7% (95% CI: 9.1%-12.2%)
- Median time in hospital during ASO spell
- 19 days (IQR: 14, 24)
- Time in hospital over first year after ASO
- 7 days (IQR: 4-10 days)
- Outpatient days beyond fifth year
- 1 outpatient day/year
- Median ASO age
- 9.5 days (IQR: 6.5-14.5 days)
Observational data: associations, not effects.
Further findings
Risk factors for late mortality and reintervention (subgroup with complete risk factor data)
- ASO age and balloon atrial septostomy (BAS) use not associated with late mortality and reintervention
- Cardiac or congenital comorbidities, low weight, and circulatory/renal support at ASO associated with late mortality and reintervention
- Subgroup n = 652
BAS followed by ASO vs ASO as first procedure (within first 3 weeks of life)
- Comparable early and late outcomes, including hospital resource utilization
- Matched for patient characteristics
Original publication
Arterial Switch for Transposition of the Great Arteries: Treatment Timing, Late Outcomes, and Risk Factors. JACC Adv. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →