Arrhythmias & electrophysiology
Association between daytime napping and incident arrhythmias: A prospective cohort study and mendelian randomization analysis
Authors' conclusion
The results of this study add to the burgeoning evidence of an association between daytime napping frequency and an increased risk of cardiac arrhythmias including AF/Af, ventricular arrhythmia, and bradyarrhythmia.
Study context
- Population
- Participants free of cardiac arrhythmias from the UK BiobankUK Biobank
- Participants
- 491,117 participants
- Exposure
- Usually napping vs never/rarely napping
- Outcome
- Incident arrhythmias: AF/flutter, ventricular arrhythmia, bradyarrhythmia
- Follow-up
- Median 11.91 years
Methodological details2-sample mendelian randomization (MR), 1-sample MR
- 2-sample MR
- 1-sample MR
Main finding
As reported in the abstract
Incident arrhythmias
Usually napping vs Never/rarely nappingHazard ratio (95% CI)
AF/Af
1.141(1.083–1.203)
Bradyarrhythmia
1.138(1.049–1.235)
- Incident AF/Af cases
- 28,801
- Incident ventricular arrhythmias
- 4132
- Incident bradyarrhythmias
- 11,616
Observational data: associations, not effects.
Further findings
Genetically predicted daytime napping frequency (MR)
| OR (95% CI) | ||
|---|---|---|
| Increased daytime napping frequencyAF/Af in FinnGen | 1.626 (1.061–2.943) | |
| Increased daytime napping frequencyBradyarrhythmia in UK Biobank | 1.005 (1.002–1.008) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Association between daytime napping and incident arrhythmias: A prospective cohort study and mendelian randomization analysis. Heart Rhythm. Published 8 February 2024. doi:10.
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