Heart failure & cardiomyopathies
Association between echocardiography-derived haemodynamic force parameters and left ventricular reverse remodelling after cardiac resynchronization therapy
Authors' conclusion
The orientation of HDF at baseline is associated with LV response to CRT. Six months after CRT, the orientation of HDF improves in LV responders and LV non-responders, while the magnitude of AB HDF only improves in LV responders.
Study context
- Population
- Patients with HF undergoing cardiac resynchronization therapy (CRT)136 (69%) left ventricular (LV) responders
- Participants
- 196 patients
- Exposure
- LV responders vs LV non-responders to CRT
- LV respondersn = 136
- Outcome
- LV response (reduction of LV end-systolic volume ≥ 15%) and its association with baseline echocardiography-derived haemodynamic forces
- Follow-up
- Six months
Main finding
As reported in the abstract
Baseline HDF associated with LV response (multivariable logistic regression)
Odds ratio (95% CI)P value
Force vector angle, complete heart cycle
1.083(1.018–1.153)
P = 0.012Systolic force vector angle
1.089(1.021–1.161)
P = 0.009Observational data: associations, not effects.
Further findings
Change in haemodynamic forces (HDF) 6 months after CRT · six months
- LV responders: greater apical-basal (AB) strength, AB impulse and higher force vector angles
- LV non-responders: improvement only in force vector angle in complete heart cycle
Original publication
Association between echocardiography-derived haemodynamic force parameters and left ventricular reverse remodelling after cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →