Association between folate deficiency and hypertension: evidence from an observational and Mendelian randomization study
Main finding · Incident hypertensionResult — go to the resultHazard ratio 1.42 95% CI 1.24–1.63Authors' conclusion
Observational and genetically determined folate deficiency were associated with hypertension, suggesting that folate deficiency might be a causal risk factor for hypertension.
Study context
- Population
- UK Biobank participants free of hypertension at enrolmentup to
- Participants
- 219,089 participants
- Exposure
- Folate deficiency vs no folate deficiency
- Outcome
- Hypertension prevalence and incidence
- Follow-up
- Median 12.8 years
Methodological detailsone-sample Mendelian randomization (MR), two-sample MR, UK Biobank
- One-sample MR
- Two-sample MR
- UK Biobank
Main finding
Incident hypertension · median 12.8 years
Hazard ratio
1.42
95% CI 1.24–1.63
Folate deficiencyvs No folate deficiency
HR 1.42 (95% CI 1.24–1.63)
As reported in the abstract
- Participants who developed hypertension
- 17 670
Observational data: associations, not effects.
Further findings
Hypertension, one-sample MR (highest quantile)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Highest quantile | 1.07 (1.04–1.10) | P for trend < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | β (95% CI) |
|---|---|
| Higher serum folate on SBP, DBP and hypertension, two-sample MRHigher serum folate · SBP | −2.313 (−3.532 to −1.094) |
| Higher serum folate on SBP, DBP and hypertension, two-sample MRHigher serum folate · DBP | −1.648 (−3.085 to −0.211) |
| Higher serum folate on SBP, DBP and hypertension, two-sample MRHigher serum folate · hypertension | −0.049 (−0.069 to −0.029) |
Original publication
Association between folate deficiency and hypertension: evidence from an observational and Mendelian randomization study. Eur J Prev Cardiol. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →