Heart failure & cardiomyopathies
Association Between Mean Arterial Pressure and Clinical Outcomes Among Patients with Heart Failure
Authors' conclusion
A higher MAP was associated with a lower risk of a composite of all-cause mortality and readmission.
Study context
- Population
- Patients with heart failure (HF) admitted to Zigong Fourth People's Hospital, 2016–2019 (PhysioNet data)
- Participants
- 2,005 patients
- Exposure
- Mean arterial pressure (MAP) tertiles
- T1n = 668reference
- T2n = 668
- T3n = 669
- Outcome
- Composite of:
- All-cause mortality
- Readmission
- Follow-up
- 3 and 6 months
Methodological detailsmultivariate-adjusted Cox regression, restricted cubic splines, propensity score matching
- Multivariate-adjusted Cox regression
- Restricted cubic splines
- Propensity score matching
Main finding
As reported in the abstract
T1
- 3 months
- 33.4% (223/668)
- 6 months
- 47.5% (317/668)
T2
- 3 months
- 24.4% (163/668)
- 6 months
- 38.5% (257/668)
T3
- 3 months
- 22.7% (152/669)
- 6 months
- 38.0% (254/669)
3 months
T133.4% (223/668)
T224.4% (163/668)
T322.7% (152/669)
6 months
T147.5% (317/668)
T238.5% (257/668)
T338.0% (254/669)
Each group vs T1Adjusted hazard ratio (95% CI)P value
T33 months
0.69(0.56–0.86)
P = 0.001T26 months
0.79(0.67–0.93)
P = 0.005T36 months
0.77(0.64–0.91)
P = 0.003Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Composite endpoint per 10 mmHg MAP increase (MAP ≤ 93 mmHg, threshold analysis) · 3 and 6 monthsPer 10 mmHg MAP increase · 3 months; 21% decrease | 0.79 (0.69–0.91) | P = 0.001 | |
| Composite endpoint per 10 mmHg MAP increase (MAP ≤ 93 mmHg, threshold analysis) · 3 and 6 monthsPer 10 mmHg MAP increase · 6 months; 14% decrease | 0.86 (0.77–0.97) | P = 0.013 | |
| 0.512Adjusted hazard ratio (log scale) |
Readmission, subgroups, sensitivity analysis · 3 and 6 months
- Associations consistent
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Mean Arterial Pressure and Clinical Outcomes Among Patients with Heart Failure. ESC Heart Fail. Published 12 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →