Heart failure & cardiomyopathies

Prognostic Significance of Pulmonary Arterial Wedge Pressure Estimated by Deep Learning in Acute Heart Failure

ESC Heart FailPublished Post hoc analysis of a prospective observational registry

Authors' conclusion

Our study suggests that ePAWP calculated by a deep learning approach may be useful for identifying and monitoring pulmonary congestion during hospitalization for ADHF.

Study context

Population
Patients admitted for acute decompensated heart failure (ADHF), January 2018–December 2019
Participants
534 patients
Comparison
ePAWP tertiles at discharge
  • First tertilen = 178reference
  • Second tertilen = 170
  • Third tertilen = 186
Primary endpoint
Composite of:
  • All-cause mortality
  • Rehospitalization for HF
Follow-up
Median 289 days
Methodological detailssingle-centre
  • Single-centre

Primary result

As reported in the abstract

Composite of:
  • All-cause mortality
  • HF rehospitalization
Adjusted
Hazard ratio (95% CI)P value
ePAWP at discharge
1.10(1.02–1.19)
P = 0.010
Size of ePAWP decrease
0.94(0.89–0.99)
P = 0.038
Significantly higher composite event rate in the third tertile (Kaplan-Meier)
P = 0.006
Primary endpoint reached
223 (41.7%)

Original publication

Prognostic Significance of Pulmonary Arterial Wedge Pressure Estimated by Deep Learning in Acute Heart Failure. ESC Heart Fail. Published 29 December 2022. doi:10.1002/ehf2.14282

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