Association between myocardial work indices and cardiovascular events according to hypertension in the general population
Authors' conclusion
Hypertension modifies the association between myocardial work indices and HF/CVD in the general population. All work indices are associated with outcome in normotensive participants. GWI, GCW, and GWE are independently associated with outcome in hypertension, but only GWE improves risk prediction.
Study context
- Population
- General population (median age 58 years, 43% men)3,932 analysed
- Participants
- 4,466 participants
- Exposure
- Myocardial work indices by hypertension status
- Outcome
- Composite of:
- HF
- CV death (HF/CVD)
- Follow-up
- Median 3.5 years
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
HF/CVD, by hypertension status (adjusted for ARIC-HF risk variables)
Hazard ratio (CI)
GWI (hypertensive)per 100 mmHg% decrease
1.12(1.07–1.16)
GCW (hypertensive)per 100 mmHg% decrease
1.12(1.08–1.17)
GWE (hypertensive)per 1% decrease
1.08(1.04–1.12)
Each row per its own increment, as printed
- Hypertension modified association between all work indices and outcome; higher risk in non-hypertensive
- P for interaction < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | C-statistic | P value |
|---|---|---|
| Incremental C-statistic of GWE added to ARIC-HF risk variables (hypertensive)ARIC-HF + GWE vs ARIC-HF · 0.865 vs. 0.877 | 0.877 | P for increment = 0.003 |
Incremental C-statistic of global work efficiency (GWE) added to ARIC-HF risk variables (hypertensive)
- Only GWE significantly increased C-statistics
Original publication
Association between myocardial work indices and cardiovascular events according to hypertension in the general population. Eur Heart J Cardiovasc Imaging. Published 1 November 2023. doi:10.
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