Association of Coronary Artery Calcium Detected by Routine Ungated Computed Tomography (CT) Imaging With Cardiovascular Outcomes
Main finding · All-cause deathResult — go to the resultHazard ratio 1.51 95% CI 1.28–1.79Authors' conclusion
Incidental CAC ≥100 was associated with an increased risk of all-cause death and adverse cardiovascular outcomes, beyond traditional risk factors.
Study context
- Population
- Adults without ASCVD with non-ECG-gated chest CT for routine care at a large academic medical centre, 2014–2019
- Participants
- 5,678 adults
- Exposure
- DL-CAC ≥100 and 1-99 vs DL-CAC = 0 on routine non-ECG-gated chest CT
- Outcome
- All-cause death
Methodological detailssingle-centre, deep-learning coronary artery calcium (CAC) quantification
- Single-centre
- Deep-learning CAC quantification
Main finding
As reported in the abstract
Hazard ratio
1.51
95% CI 1.28–1.79
DL-CAC ≥100vs DL-CAC = 0
HR 1.51 (95% CI 1.28–1.79)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Death/MI/strokeDL-CAC ≥100vs DL-CAC = 0Adjusted | 1.57 (1.33–1.84) | |
| Death/MI/stroke/revascularizationDL-CAC ≥100vs DL-CAC = 0Adjusted | 1.69 (1.45–1.98) | |
| 0.512Hazard ratio (log scale) |
- Risk profile and statin use in DL-CAC ≥100
- 24% · Average 10-year ASCVD risk · On statins 26%
Prevalence of DL-CAC >0
- DL-CAC >0
- 52%
Original publication
Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes. J Am Coll Cardiol. Published 19 September 2023. doi:10.
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