Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease
Authors' conclusion
Long-term cumulative RC was independently associated with incident MACE in elderly participants with ASCVD
Study context
- Population
- Patients aged ≥75 years with atherosclerotic cardiovascular disease; baseline visits 2006–2012 followed by four in-person visits
- Participants
- 4,680 patients
- Exposure
- High vs low tertile of cumulative and time-weighted average remnant cholesterol
- Outcome
- MACE:
- Stroke
- Unstable angina pectoris
- MI
- Cardiac death
- Follow-up
- Median 6.1 years (IQR 3.4-6.6 years) from the fourth visit
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
MACE
High tertile vs Low tertileHazard ratio (95% CI)
Cumulative RC
1.30(1.16–1.44)
TWA RC
1.36(1.23–1.52)
Observational data: associations, not effects.
Further findings
Major adverse cardiovascular events (MACE), propensity score analyses
- Consistent significant associations in most propensity score analyses
Original publication
Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease. Eur J Prev Cardiol. Published 14 September 2023. doi:10.
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