Arrhythmias & electrophysiology

Association of Race and Ethnicity With Stroke and Mortality Outcomes in Atrial Fibrillation

JACC AdvPublished nationwide cohort

Authors' conclusion

In a nationwide cohort of AF patients, we found significantly higher stroke rates for Black than White patients. Conversely, we observed significantly lower mortality rates for Asian, Black, and Hispanic patients than for White patients. Interventions to address factors associated with these disparities are essential.

Study context

Population
Veterans Health Administration patients with incident atrial fibrillation (AF) from January 1, 2014, to December 31, 2021, with follow-up through May 31, 2022patients with AF, mean age 72.9 ± 10.5 years, 97.8% male and 2.2% female
Participants
157,332 patients
Exposure
Stroke and mortality by race and ethnicity for AF patients in the Veterans Health Administration
Outcome
Stroke and mortality incidence
Methodological detailsCox proportional hazard models, adjusting for sociodemographic, clinical, and facility factors
  • Cox proportional hazard models
  • Adjusting for sociodemographic, clinical, and facility factors

Main finding

As reported in the abstract

Each group vs whiteAdjusted hazard ratio (95% CI)
Blackstroke; higher for Black
1.14(1.09–1.20)
Asianmortality; lower for Asian
0.85(0.78–0.93)
Blackmortality; lower for Black
0.92(0.89–0.95)
Hispanicmortality; lower for Hispanic
0.82(0.77–0.87)
Stroke, overall
22,628 (14.7%) patients (46.3 per 1,000 person-years)
Died, overall
52,288 (33.2%) patients (96.1 per 1,000 person-years)

Observational data: associations, not effects.

Original publication

Association of Race and Ethnicity With Stroke and Mortality Outcomes in Atrial Fibrillation. JACC Adv. Published 5 June 2025. doi:10.1016/j.jacadv.2025.101860

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