Association and predictive value of immunoglobulin and complement levels for incident coronary heart disease: a nested case-control study in Chinese adults
Authors' conclusion
Our study identified IgA and C3 as independent risk factors and IgG as a protective factor for CHD.
Study context
- Population
- Chinese adults in the Dongfeng-Tongji cohort
- Participants
- 1,605 vs 1,605
- Comparison
- Higher vs lower serum immunoglobulin and complement levels
- Coronary heart disease (CHD) casesn = 1,605
- Controlsn = 1,605reference
- Outcome
- Incident CHD by serum IgA, IgE, IgG, IgM, C3 and C4 levels
Methodological detailsage- and sex-matched, within the Dongfeng-Tongji cohort
- Age- and sex-matched
- Within the Dongfeng-Tongji cohort
Main finding
As reported in the abstract
Incident CHD
Odds ratio (95% CI)P value
Higher IgAlinear association
1.35(1.11–1.62)
P = 0.002Higher C3linear association
2.01(1.17–3.44)
P = 0.01Higher IgGlinear decrease in risk
0.55(0.36–0.83)
P = 0.005Observational data: associations, not effects.
Further findings
Mediation by C-reactive protein (CRP)
- Proportion of IgA–CHD association mediated by CRP
- 5.70%
- Proportion of C3–CHD association mediated by CRP
- 12.51%
Added predictive value beyond traditional risk model: immune indicator score vs CRP
- AUC improvement, immune score vs CRP
- 0.85% vs. 0.21%
- Net reclassification improvement (NRI), immune score vs CRP
- 15.33% vs. 7.85%
- Integrated discrimination improvement (IDI), immune score vs CRP
- 0.80% vs. 0.17%
Original publication
Association and predictive value of immunoglobulin and complement levels for incident coronary heart disease: a nested case-control study in Chinese adults. Eur J Prev Cardiol. Published 28 March 2025. doi:10.
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