Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis
Pooled result · MACEResult — go to the resultRelative risk 1.97 95% CI 1.45–2.67Authors' conclusion
We found no clear continuous association between post-PCI FFR and clinical outcomes in this systematic study-level meta-analysis. In a subset of studies investigating binary classification, high post-PCI FFR was associated with a better clinical outcome than low post-PCI FFR.
Study context
- Population
- Patients after PCI with final post-PCI fractional flow reserve (FFR) measured, studies with clinical follow-up
- Participants
- 12,340 patients62 studies
- Comparison
- Low vs high post-PCI FFR
- Outcome
- MACE:
- All-cause death
- Myocardial infarction (MI)
- TVR
Methodological detailsstudy-level meta-analysis, meta-regression, Follow-up 1 to 89 months; 12 923 stented vessels
- Study-level meta-analysis
- Meta-regression
- Follow-up 1 to 89 months; 12 923 stented vessels
Pooled result
MACE
Relative risk
1.97
95% CI 1.45–2.67
Low post-PCI FFRvs High post-PCI FFR
RR 1.97 (95% CI 1.45–2.67)
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| All-cause death, MI, TVR, angina statusLow post-PCI FFRvs High post-PCI FFRAll-cause death | 1.59 (1.08–2.34) | |
| All-cause death, MI, TVR, angina statusLow post-PCI FFRvs High post-PCI FFRMI | 3.18 (1.84–5.50) | |
| All-cause death, MI, TVR, angina statusLow post-PCI FFRvs High post-PCI FFRTVR | 2.08 (1.63–2.65) | |
| All-cause death, MI, TVR, angina statusLow post-PCI FFRvs High post-PCI FFRAngina status | 2.50 (1.53–4.06) | |
| 0.20.5125Relative risk (log scale) |
1-year target vessel revascularization (TVR) (meta-regression)
- Post-PCI FFR not continuously associated with 1-year TVR
Original publication
Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis. Eur Heart J Qual Care Clin Outcomes. Published 26 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →