Heart failure & cardiomyopathies
Associations Between Cardiac Function and Brain Health in Diverse Middle-Aged Adults: The Dallas Heart Study-2
Authors' conclusion
Subclinical cardiac dysfunction indicated by LVEF was associated with lower cognitive function. Moreover, LV mass and concentric remodeling were associated with higher WMH burden, particularly among Black individuals.
Study context
- Population
- Middle-aged adults in the Dallas Heart Study phase 2 (46% Black)46% Black
- Participants
- 1,919 adults
- Outcome
- Associations of CMR cardiac measures (LV mass, LVEF, LV concentricity, peak systolic strain [LV Ecc]) with WMH volume and Montreal Cognitive Assessment score
Methodological detailsmultiethnic cohort
- Multiethnic cohort
Main finding
As reported in the abstract
LVEF vs total Montreal Cognitive Assessment score, β (95% CI 0.003-0.12), P = 0.042
0.06
Left ventricular (LV) Ecc vs white matter hyperintensities (WMH) volume, β (95% CI 0.01-0.14), P = 0.025
0.08
LV mass vs WMH volume, β (95% CI 0.03-0.23), P = 0.008
0.13
LV concentricity vs WMH volume, β (95% CI 0.03-0.17), P = 0.005
0.10
Observational data: associations, not effects.
Further findings
LV mass and concentricity vs WMH volume, by race (Black vs White)
- LV mass, Black: β
- 0.17 (95% CI 0.04-0.30)
- LV mass, White: β
- −0.009 (95% CI −0.16 to 0.14)
- LV concentricity, Black: β
- 0.22 (95% CI 0.13-0.32)
- LV concentricity, White: β
- −0.11 (95% CI −0.21 to −0.01)
- Black vs White P = 0.036 (LV mass)
- Black vs White P < 0.0001 (concentricity)
Original publication
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