Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study
Authors' conclusion
Elevated RC levels in young adulthood were related to adverse LV structural and functional alterations in midlife.
Study context
- Population
- Young adults in the CARDIA study (mean age 24.99±3.62 years; 43.90% male, 47.00% Black)
- Participants
- 3,321 adults
- Exposure
- Higher vs lower remnant cholesterol (RC) in young adulthood
- Outcome
- LV structure and function by echocardiography
- Follow-up
- CARDIA study year 25
Methodological detailsmultivariable linear regression, latent class growth mixture model trajectories
- Multivariable linear regression
- Latent class growth mixture model trajectories
Main finding
As reported in the abstract
year 25
- Higher left ventricular (LV) mass index, β
- 1.29; P=0.004
- Worse global longitudinal strain, β
- 0.19; P<0.001
- Worse global circumferential strain, β
- 0.16; P=0.014
- Lower septal e', β
- −0.26; P<0.001
- Lower lateral e', β
- −0.18; P=0.003
- Higher E/e', β
- 0.15; P=0.003
Observational data: associations, not effects.
Further findings
LV structure and function by RC trajectory
- High increasing vs Low increasing: higher LV mass index, worse global longitudinal strain, lower septal e', lower lateral e', higher E/e'
Original publication
Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study. Circ Cardiovasc Imaging. Published 21 November 2023. doi:10.
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