Valvular & structural heart disease
Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration
Authors' conclusion
The dominant VA in AMVP was VF, although SMVT was also common and associated with older age, family history of SCD, syncope, and myocardial LGE. The most common initiation was pause dependent leading to VF.
Study context
- Population
- Patients with arrhythmic mitral valve prolapse (AMVP) and documented sustained ventricular arrhythmia
- Participants
- 225 patients · 35 centres
Methodological detailsmulticentre, 35 centres, core laboratory analysis of tracings
- Multicentre
- 35 centres
- Core laboratory analysis of tracings
Main finding
As reported in the abstract
Types and triggers of sustained ventricular arrhythmias
- Arrhythmic events collected
- 278
- Ventricular fibrillation (VF) (most frequent)
- 65%
- Sustained monomorphic VT (sustained monomorphic ventricular tachycardia (SMVT))
- 26%
- Trigger: exercise or stress
- 37%
- No discernible trigger
- 31%
Observational data: associations, not effects.
Further findings
Factors associated with SMVT
- Increasing age
- P = 0.03
- Family history of sudden cardiac death (SCD)
- P = 0.03
- History of syncope
- P = 0.05
- Myocardial late gadolinium enhancement (LGE)
- P = 0.003
Initiation mechanisms (events with available tracings)
- Events with available tracings
- 140 (50%)
- Triggered by short-coupled PVC
- 25%
- Pause-dependent initiation (most frequent)
- 49%
- Pause-dependent initiation more likely to lead to VF than SMVT
- P = 0.01
Late gadolinium enhancement
- LGE present
- 61%
Original publication
Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration. JACC Clin Electrophysiol. Published 20 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it