Arrhythmias & electrophysiology
Atrial fibrillation and chronic obstructive pulmonary disease: diagnostic sequence and mortality risk
Authors' conclusion
Patients with concomitant AF and COPD had a very poor prognosis and the temporal sequence in diagnosis was differentially associated with prognosis, where a COPD diagnosis preceding an AF diagnosis was accompanied with a higher mortality risk compared with a COPD diagnosis following an AF diagnosis.
Study context
- Population
- Patients aged 18–85 years diagnosed with both chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF), Denmark, 1999–201831,494 (50.1%) died
- Participants
- 62,806 patients
- Exposure
- COPD diagnosed before AF, or AF and COPD diagnosed within 6 months, vs AF diagnosed before COPD
- Outcome
- All-cause mortality
- Follow-up
- 5 years
Methodological detailsDenmark
- Denmark
Main finding
As reported in the abstract
Mortality
Each group vs AF-FirstHazard ratio (95% CI)P value
AF∼COPD
1.19(1.16–1.23)
P < 0.001COPD-First
1.30(1.27–1.33)
P < 0.001Observational data: associations, not effects.
Further findings
Timing of COPD diagnosis (restricted cubic spline)
- The earlier COPD was diagnosed, the worse the prognosis
Original publication
Atrial fibrillation and chronic obstructive pulmonary disease: diagnostic sequence and mortality risk. Eur Heart J Qual Care Clin Outcomes. Published 7 September 2022. doi:10.
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