Arrhythmias & electrophysiology
Atrial Translocation of Porphyromonas gingivalis Exacerbates Atrial Fibrosis and Atrial Fibrillation
Authors' conclusion
P gingivalis translocation to the left atrium correlates with the clinical severity of periodontitis, which may exacerbate atrial fibrosis and AF.
Study context
- Population
- P gingivalis-infected C57BL/6J mice; patients with atrial fibrillation (AF) providing left atrial appendage specimenspatients with AF
- Participants
- 68 mice
- Comparison
- P gingivalis-infected vs control mice; P gingivalis load vs periodontitis severity and atrial fibrosis in patients with AF
- Outcome
- Atrial fibrosis and AF inducibility (P gingivalis-infected vs control mice)
Methodological detailsmouse model, human atrial tissue analysis
- Mouse model
- Human atrial tissue analysis
Main finding
As reported in the abstract
Atrial fibrosis
P = 0.0003
AF inducibility
P = 0.04
Original publication
Atrial Translocation of Porphyromonas gingivalis Exacerbates Atrial Fibrosis and Atrial Fibrillation. Circulation. Published 18 March 2025. doi:10.
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