Arrhythmias & electrophysiology
Atrioventricular Synchrony Delivered by a Dual-Chamber Leadless Pacemaker System
Authors' conclusion
This dual-chamber leadless pacemaker system demonstrated atrioventricular synchrony in 98% of evaluable beats at 3 months after implantation. Atrioventricular synchrony was maintained across postures/activities and remained robust for heart rates >100 bpm.
Study context
- Population
- Patients with a conventional dual-chamber pacing indication, enrolled February 2022 to March 2023384 evaluable
- Participants
- 464 patients
- Outcome
- Percent of AV synchronous beats (300-ms PR interval limit) on 12-lead Holter across postures/activities, core-lab adjudicated
- Follow-up
- 3 months after implantation
Methodological detailsunblinded, multicenter, international, post hoc analyses
- Unblinded
- Multicenter
- International
- Post hoc analyses
Main finding
As reported in the abstract
AV synchrony (% of beats, 300-ms PR limit) vs i2i communication success
- Mean AV synchrony across all postures
- 98%
- Atrial-to-ventricular i2i
- 94%
- Ventricular-to-atrial i2i
- 94%
- AV synchrony greater than both i2i values
- P<0.001
- AV synchrony exceeded both i2i values in % of patients
- 95%
Observational data: associations, not effects.
Further findings
AV synchrony by posture/activity, implantation indication, AV paced/sensed event combination and heart rate range (post hoc) · 3 months
- AV synchrony achieved in >95% of evaluable beats across all categories, including heart rate >100 bpm
- Post hoc
Original publication
Atrioventricular Synchrony Delivered by a Dual-Chamber Leadless Pacemaker System. Circulation. Published 8 July 2024. doi:10.
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