Arrhythmias & electrophysiology
Autoimmune Atrial Fibrillation
Authors' conclusion
To our knowledge, this is the first report of an autoimmune pathogenesis of AF with direct evidence of Kir3.4 autoantibody-mediated AF.
Study context
- Population
- Patients with unexplained atrial fibrillation (AF)
- Participants
- 37 / 14 / 37
- Comparison
- Patients with unexplained AF vs age- and sex-matched controls
- Pre-existent AFn = 37
- Incident AFn = 14
- Controlsn = 37reference
- Outcome
- Autoantibodies targeting cardiac ion channels underlying unexplained AF
Methodological detailscase-control screening, age- and sex-matched controls, in vitro patch clamp, mouse immunization model
- Case-control screening
- Age- and sex-matched controls
- In vitro patch clamp
- Mouse immunization model
Main finding
As reported in the abstract
Kir3.4-immunized mice: increased susceptibility to AF (fold)
2.8
Original publication
Autoimmune Atrial Fibrillation. Circulation. Published 4 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →