Heart failure & cardiomyopathies
Biologically Active Adrenomedullin as a Marker for Residual Congestion and Early Rehospitalization in Patients Hospitalized for Acute Heart Failure: Data from STRONG-HF
An erratum to this article was published (Eur J Heart Fail, Jan 2025 ↗)
Primary resultResult — go to the resultHazard ratio 2.14 95% CI 1.42–3.22Authors' conclusion
Bio-ADM is a marker of congestion and predicts congestion at 3 months after a HF hospitalization. Higher bio-ADM was modestly associated with a higher risk of death and early hospital readmission and may have added value when combined with NT-proBNP.
Study context
- Population
- Patients hospitalised for acute heart failure (HF) (STRONG-HF); bio-ADM measured within 2 days before anticipated discharge and 90 days later
- Participants
- 1,005 patients
- Comparison
- Highest vs lowest tertile of baseline bio-ADM
- Primary endpoint
- All-cause mortality or HF rehospitalization
- Follow-up
- 180 days
Primary result
As reported in the abstract
Hazard ratio
2.14
95% CI 1.42–3.22
Highest tertilevs Lowest tertile
HR 2.14 (95% CI 1.42–3.22)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| 180-day HF rehospitalization | 2.33 (1.38–3.94) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | bio-ADM | NT-proBNP | bio-ADM + NT-proBNP | P value |
|---|---|---|---|---|
| Discrimination of primary outcome (ROC AUC)bio-ADM + NT-proBNP vs NT-proBNP · trend towards better discrimination | P = 0.059 | |||
| AUC | 0.5977 (95% CI 0.5561-0.6393) | 0.5800 (95% CI 0.5356-0.6243) | 0.6159 (95% CI 0.5711-0.6607) |
Correlation of bio-ADM change with change in congestion status (baseline to day 90)
- Gamma
- −0.24
- p
- P = 0.0001
Effect of high-intensity care (HIC) vs usual care on primary outcome by baseline bio-ADM
- HIC improved the primary outcome irrespective of baseline bio-ADM
- Interaction p = 0.37
90-day change in bio-ADM, HIC vs usual care
- Did not differ significantly between HIC and usual care (in contrast to NT-proBNP)
Original publication
Biologically Active Adrenomedullin as a Marker for Residual Congestion and Early Rehospitalization in Patients Hospitalized for Acute Heart Failure: Data from STRONG-HF. Eur J Heart Fail. Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →